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Our research program is focused on understanding early events of HIV-1 infection such as uncoating, reverse transcription and nuclear import. To this end, we have exploited a group of proteins that are expressed by the host, and block HIV-1 infection at early stages. These proteins, known as restriction factors, have allowed us to understand fundamental processes in the HIV-1 life cycle. Besides assisting the understanding of fundamental problems on HIV-1 biology, restriction factors represent a new frontier in the search for an effective HIV-1 cure. If you are a Post-Doc or PhD student interested in joining the lab send me an email or come by the lab.