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Capsid Binding Assay

The capsid binding assay is an in vitro assay that is capable of determining if proteins directly interact with HIV-1 capsid by using HIV-1 CA-NC complexes assembled in vitro.  The assay can test protein mutants as well as capsid mutants.

Diaz-Griffero F, Vandergraaff N, Li U, McGee-Estrada K, Stremlau M, Welikala S, Si Z, Engelman Al, Sodroski J. Requirements for capsid-binding and an effector function in TRIMCym-mediated restriction of HIV-1. 2006. Virology; 351(2): 404-419. DOI:10.1016/j.virol.2006.03.023

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